Regulation of Eukaryotic Initiation Factor 4E and Its Isoform: Implications for Antiviral Strategy in Plants |
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作者姓名: | Yu-Yang Zhang Han-Xia Li Bo Ouyang Zhi-Biao Ye |
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作者单位: | [1]National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China [2]College of Horticulture and Forestry, Huazhong Agricultural University, Wuhan 430070, China |
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基金项目: | Supported by the Hi-Tech Research and Development Plan (863) of China (2001AA212221) and the National Natural Science Foundation of China (30270914). |
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摘 要: | In recent years, biotechnology has permitted regulation of the expression of endogenous plant genes to improve agronomlcally important traits. Genetic modification of crops has benefited from emerging knowledge of new genes, especially genes that exhibit novel functions, one of which is eukaryotlc initiation factor 4E (eIF4E). eIF4E Is one of the most important translation initiation factors Involved in eukaryotic initiation. Recent research has demonstrated that virus resistance mediated by eIF4E and Its isoform elf (Iso)4E occurs in several plant-virus interactions, thus indicating a potential new role for eIF4E/elF(Iso)4E In resistance strategies against plant viruses. In this review, we briefly describe eIF4E activity In plant translation, its potential role, and functions of the eIF4E subfamily In plant-virus interactions. Other initiation factors such as elF4G could also play a role In plant resistance against viruses. Finally, the potential for developing eIF4E-mediated resistance to plant viruses in the future Is discussed. Future research should focus on elucidation of the resistance mechanism and spectrum mediated by eIF4E. Knowledge of a particu- lar plant-virus interaction will help to deepen our understanding of eIF4E and other eukaryotic Initiation factors, and their involvement in virus disease control.
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关 键 词: | 真核细胞 对碘氧基苯甲醚 抗病毒 治疗 |
收稿时间: | 2005-06-21 |
修稿时间: | 2005-06-212005-09-19 |
Regulation of Eukaryotic Initiation Factor 4E and Its Isoform: Implications for Antiviral Strategy in Plants |
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Authors: | Yu-Yang Zhang Han-Xia Li Bo Ouyang Zhi-Biao Ye |
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Institution: | National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China;;College of Horticulture and Forestry, Huazhong Agricultural University, Wuhan 430070, China |
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Abstract: | In recent years, biotechnology has permitted regulation of the expression of endogenous plant genes to improve agronomically important traits. Genetic modification of crops has benefited from emerging knowledge of new genes, especially genes that exhibit novel functions, one of which is eukaryotic initiation factor 4E (eIF4E). eIF4E is one of the most important translation initiation factors involved in eukaryotic initiation. Recent research has demonstrated that virus resistance mediated by eIF4E and its isoform eIF (iso)4E occurs in several plant‐virus interactions, thus indicating a potential new role for eIF4E/eIF(iso)4E in resistance strategies against plant viruses. In this review, we briefly describe eIF4E activity in plant translation, its potential role, and functions of the eIF4E subfamily in plant‐virus interactions. Other initiation factors such as eIF4G could also play a role in plant resistance against viruses. Finally, the potential for developing eIF4E‐mediated resistance to plant viruses in the future is discussed. Future research should focus on elucidation of the resistance mechanism and spectrum mediated by eIF4E. Knowledge of a particular plant‐virus interaction will help to deepen our understanding of eIF4E and other eukaryotic initiation factors, and their involvement in virus disease control. (Managing editor: Li‐Hui Zhao) |
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Keywords: | eIF4E antivirus eukaryotic initiation factors interaction plant |
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