Association of CYBA G640A variation with coronary artery disease in Indians |
| |
Authors: | Sripriya Natarajan Chandrashekhar K. Ponde Rajesh M. Rajani |
| |
Affiliation: | 1. Research Laboratories, P.D. Hinduja Hospital &2. MRC, Mumbai, Maharashtra, India;3. Department of Medicine, P. D. Hinduja Hospital & |
| |
Abstract: | Introduction: Oxidative stress induces atherosclerosis by triggering an inflammatory cascade within the vascular wall.Objective: To investigate the role of pro-oxidant and antioxidant gene variations with CAD in Indian subjects.Materials & methods: It’s a case-control study and genotyping for the variants MPO G-463A, CYBA G640A, SOD2 Val16Ala and CAT C-262T were performed by conventional PCR techniques.Results: Only CYBA G640A variant allele was found to be significantly (p?=?0.0075) associated with CAD.Conclusion: Although CYBA G640A variation was found to be significant, a larger study is needed to validate these results and establish its role as a biomarker. |
| |
Keywords: | Coronary artery disease CYBA gene polymorphisms Indians oxidative stress |
|
|