The influence of heart failure co-morbidity on high-sensitivity troponin T levels in COPD exacerbation in a prospective cohort study: data from the Akershus cardiac examination (ACE) 2 study |
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| Authors: | Arne Didrik Høiseth Jon Brynildsen Tor-Arne Hagve Geir Christensen Vidar Søyseth Omland Torbjørn |
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| Affiliation: | 1. Division of Medicine, Akershus University Hospital, L?renskog, Norway,;2. Center for Heart Failure Research and K.G. Jebsen Cardiac Research Centre, Institute of Clinical Medicine;3. University of Oslo, Oslo, Norway, a.d.hoiseth@medisin.uio.no;5. University of Oslo, Oslo, Norway,;6. Division of Diagnostics and Technology, Akershus University Hospital, L?renskog, Norway, and;7. Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway;8. Center for Heart Failure Research and K.G. Jebsen Cardiac Research Centre, Institute of Clinical Medicine |
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| Abstract: | Context: Troponin (hs-TnT) levels predict mortality after acute exacerbation of COPD (AECOPD). Whether this is independent of heart failure (HF) is not established.Material and methods: Prospectively included AECOPD patients adjudicated for acute HF categorized into three groups: (A) AECOPD, but acute HF the primary cause for hospitalization; (B) AECOPD the primary cause, but co-existing myocardial dysfunction and (C) AECOPD without myocardial dysfunction.Results: About 103 AECOPD patients; 18% A, 27% B and 54% C. Hs-TnT level differed between the groups: (ng/l, median) A: 41, B: 25 and C: 15, p?=?0.03 for A versus B and p?=?0.005 for B versus C. During a median 826 days, 47% died. In Cox analysis, hs-TnT levels remained associated with mortality (hazard ratio per 10?ng/l 1.3, p?Conclusion: hs-TnT levels are influenced by myocardial dysfunction/HF in AECOPD, but provide independent prognostic information. The prognostic merit of hs-TnT cannot be attributed to HF alone. |
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| Keywords: | COPD epidemiology heart failure troponin |
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