Hemostatic,inflammatory, and oxidative markers in pesticide user farmers |
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| Authors: | Fatima Zohra Madani Sid Ahmed Merzouk Bouchra Loukidi Katia Taouli Michel Narce |
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| Affiliation: | 1. Laboratory of Physiology and Biochemistry of Nutrition, Department of Biology, Faculty of Sciences, University Abou-Bekr Belka?d, Tlemcen, Algeria,;2. Department of Technical Sciences, Faculty of Engineering, University Abou-Bekr Belka?d, Tlemcen, Algeria,;3. Department of Hemobiology, Tlemcen Hospital, Tlemcen, Algeria, and;4. INSERM UMR 866, ‘‘Lipids Nutrition Cancer’’, University of Burgundy, Faculty of Sciences, Dijon, France |
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| Abstract: | The aim of this work was to investigate inflammatory, oxidative, and thrombotic parameters as biomarkers in farmers exposed to pesticides. Fifty farmers using chemical pesticides and 60 unexposed control men participated in this study. The Mediterranean diet compliance, the duration of pesticide use, and personal protection for pesticides handling were recorded using self-administered questionnaires. Serum biochemical parameters, oxidant/antioxidant, inflammatory, and thrombosis markers were determined. Our findings showed oxidative stress reflected by an increase in malondialdehyde, carbonyl proteins and superoxide anion levels and a decrease in vitamins C and E, glutathione, catalase, and superoxide dismutase activities in farmers. Serum C-reactive protein, prothrombin, and fibrinogen levels were enhanced in these farmers. In conclusion, inflammation, oxidative stress, and metabolic perturbations reflected the possibility of the effects of pesticides to farmers. |
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| Keywords: | Farmers inflammation oxidative stress pesticide thrombosis |
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