Polymorphisms in the MTHFR and MTR genes and the risk of varicose veins in ethnical Russians |
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| Authors: | Alexandra Sergeevna Shadrina Kseniya Sergeevna Sevost'ianova Andrey Ivanovich Shevela Evgenii Yurievich Soldatsky Evgenii Igorevich Seliverstov Marina Yurievna Demekhova |
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| Affiliation: | 1. Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;2. Novosibirsk State University, Novosibirsk, Russia;3. weiner.alexserg@gmail.com;5. Pirogov Russian National Research Medical University, Moscow, Russia;6. Private Surgery Center “Medalp”, Saint Petersburg, Russia |
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| Abstract: | Objectives: The objective of this study was to study the association of polymorphisms MTHFR C677T (rs1801133) and MTR A2756G (rs1805087) with the risk of varicose veins in ethnical Russians.Methods: We genotyped 475 patients with varicose veins, 168 individual without chronic venous disease, and the population-based group of 896 subjects. Association was studied using logistic regression analysis adopting co-dominant, additive, recessive, and dominant models of inheritance.Results: None of the polymorphisms showed a statistically significant association with the risk of varicose veins.Conclusions: Our results provide evidence that the studied polymorphisms do not contribute to genetic susceptibility to varicose veins in ethnical Russians. |
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| Keywords: | Association folate-metabolizing genes SNP |
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