Plasma and synovial fluid inflammatory cytokine profiles in primary knee osteoarthritis |
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| Authors: | Thomas Mabey Aree Tanavalee Pongsak Yuktanandana Vajara Wilairatana Yong Poovorawan |
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| Institution: | 1. Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand;2. Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand;3. Department of Pediatrics Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand |
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| Abstract: | Objective: The objective of this study is to compare inflammatory cytokine levels in primary knee osteoarthritis (OA) patients and healthy controls.Methods: A total of 32 knee OA patients and 14 healthy controls were enrolled. A multiplex immunoassay was utilized for 10 cytokines in plasma and synovial fluid.Results: Plasma IL-2, IL-4, and IL-6 concentrations were significantly greater in knee OA patients than controls. Moreover, both plasma IL-4 and IL-6 were positively correlated with the radiographic severity of knee OA.Conclusions: Plasma IL-4 and IL-6 may serve as biomarkers reflecting the severity of OA. |
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| Keywords: | Anti-inflammatory cytokines osteoarthritis plasma proinflammatory synovial fluid |
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