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Albumin and apolipoprotein H mRNAs in human plasma as potential clinical biomarkers of liver injury: analyses of plasma liver-specific mRNAs in patients with liver injury |
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| Authors: | Shingo Okubo Makoto Miyamoto Dai Ito Kenji Takami Kiyoshi Ashida |
| Institution: | 1. Drug Safety Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan and shingo.okubo@takeda.com;3. Drug Safety Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan and;4. Department of Gastroenterology and Hepatology, Osakafu Saiseikai Nakatsu Hospital, Osaka, Japan |
| Abstract: | Context: Plasma liver-specific mRNAs are useful biomarkers of hepatotoxicity in rats.Objective: To investigate the potential application of liver-specific mRNAs as biomarkers for liver injury in humans.Methods: We determined the plasma levels of liver-specific mRNAs by real-time qRT-PCR in healthy donors and patients with liver injury.Results: Plasma levels of albumin (ALB) and apolipoprotein H (APOH) mRNAs increased in patients with elevated serum alanine aminotransferase. These mRNAs also increased in plasma after transcatheter arterial chemoembolization, which induces specific injury to liver.Conclusions: We demonstrated the potential application of plasma ALB and APOH mRNAs as clinical biomarkers for liver injury. |
| Keywords: | Circulating mRNAs clinical application liver injury real-time qRT-PCR TACE |