Evaluation of mediators of oxidative stress and inflammation in patients with acute appendicitis |
| |
| Authors: | Sandra Lorena de Oliveira Machado Pauline da Costa Jucimara Baldissarelli Karine Paula Reichert Lizielle Souza de Oliveira |
| |
| Institution: | 1. Department of Surgery at University Hospital of Santa Maria, Federal University of Santa Maria, Santa Maria, Brazil;2. Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, Brazil |
| |
| Abstract: | Context: This study aims to explore the potential of new inflammatory markers for improving the challenging diagnosis of acute appendicitis (AA).Methods: Levels of IL-1, IL-6, IL-8, IL-10, CRP, INF-γ, and TNF-α in serum were measured in 73 patients with AA. Oxidative stress and antioxidant enzymes were analyzed.Results: Serum levels of interleukins, TNF-α, and INF-γ were significantly elevated in patients with appendicitis (p?<?0.0001), except for IL-10, which presented decreased levels. There were no significant differences in SOD (p?=?0.29), CAT (p?=?0.19), or TBARS levels (p?=?0.18), whereas protein carbonyls presented significant increase (p?<?0.0001).Conclusion: Evaluating these biomarkers could aid in diagnosing AA. |
| |
| Keywords: | Cytokines growth factors inflammatory bowel disease inflammatory mediators oxidative stress |
|
|
