Identification of potential biomarkers for post-traumatic complications released after trauma–hemorrhage from murine Kupffer cells and its investigation in lung and liver |
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| Authors: | Cornelia Schultze Frank Hildebrand Sandra Noack Christian Krettek Christian Zeckey |
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| Institution: | 1. Trauma Department, Hannover Medical School, Hannover, Germany;2. Department of Orthopaedics and Trauma Surgery, University Hospital Aachen, Aachen, Germany |
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| Abstract: | Context: Early diagnosis of complications after severe trauma by specific biomarkers remains difficult.Objective: Identify potential new biomarkers for early diagnosis of post-traumatic complications.Material and methods: Mice underwent pressure-controlled hemorrhage or sham procedure. Four hours later, genome-wide expression of isolated Kupffer cells was compared with controls using Affymetrix-Genechip-Expression-Analysis and real-time-PCR.Results: Expression analysis and real-time-PCR revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5.Conclusion: Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5 might represent new biomarkers for early diagnosis of post-traumatic complications, if they are linked to the development of post-traumatic complications. |
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| Keywords: | Csf2rb2 Cxcl10 Gbp5 Il4ra Lcn2 multiple trauma |
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