Novel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold |
| |
| Authors: | Mikhail Krasavin Alexey Lukin Nikolay Zhurilo Alexey Kovalenko Ihor Zahanich Sergey Zozulya |
| |
| Affiliation: | 1. Department of Organic Chemistry, Institutes of Chemistry and Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russian Federation, m.krasavin@spbu.ru;3. Lomonosov Moscow State Institute of Fine Chemical Technologies (MITHT), Moscow, Russian Federation,;4. Enamine Ltd, 78 Chervonotkatska, Kyiv, Ukraine, and;5. Enamine Ltd, 78 Chervonotkatska, Kyiv, Ukraine, and;6. Taras Shevchenko National University, 62 Volodymyrska, Kyiv, Ukraine |
| |
| Abstract: | 1,3,4-Thiadiazole was explored as a more polar, heterocyclic replacement for the phenyl ring in the 3-arylpropionic acid pharmacophore present in the majority of GPR40 agonists. Out of 13 compounds synthesized using a flexible, three-step protocol (involving no chromatographic purification), four compounds were confirmed to activate the target in micromolar concentration range. While the potency of the series should be subject of further optimization, the remarkable aqueous solubility and microsomal stability observed for the lead compound (8g) apparently attests to this new scaffold’s high promise in the GPR40 agonist field. |
| |
| Keywords: | Agonists aqueous solubility bioisosteric replacement cLogP free fatty acid receptor 1 GPR40 metabolic stability total polar surface area |
|
|
