Relaxant effects of selected sildenafil analogues in the rat aorta |
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| Authors: | Mariusz Mojzych Monika Kubacka Szczepan Mogilski Barbara Filipek Emilia Fornal |
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| Institution: | 1. Department of Chemistry, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland, mmojzych@yahoo.com;3. Department of Pharmacodynamics, Jagiellonian University Medical College, Kraków, Poland, and;4. Department of Chemistry, Laboratory of Separation and Spectroscopic Method Applications, Center for Interdisciplinary Research, The John Paul II Catholic University of Lublin, Lublin, Poland |
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| Abstract: | A new series of sulfonamide derivatives of pyrazolo4,3-e]1,2,4]triazine with chiral amino group has been synthesized and characterized. The compounds were tested for their relaxant effects in the rat aorta. Evaluation of prepared derivatives demonstrated that compound (8a) is probably a non-selective phosphodiesterase (PDE) inhibitor, as it induced aortic relaxation through endothelium-independent mechanism. |
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| Keywords: | PDE5 inhibitors pyrazolo[4 3-e][1 2 4]triazine relaxant effect sildenafil analogues sulfonamides |
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