Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety |
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Authors: | Leyla Yurtta? Zafer As?m Kaplanc?kl? Gamze Göger Fatih Demirci |
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Institution: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eski?ehir, Turkey, lyurttas@anadolu.edu.tr;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eski?ehir, Turkey,;4. Department of Pharmacognosy, Graduate School of Health Sciences, Anadolu University, Eski?ehir, Turkey, and;5. Faculty of Health Sciences, Anadolu University, Eski?ehir, Turkey |
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Abstract: | In this study, we have performed the synthesis of new N′-(arylidene)-4-(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a–s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target compounds were prepared by a three step synthetic procedure starting from 2-mercaptobenzothiazole. The structures of the target compounds were elucidated by IR, 1H NMR, 13C NMR spectra and elemental analysis. The antifungal activity of the obtained compounds has been determined against a number of clinic and fluconazole-resistant Candida strains by using microdilution method. Compounds (3a–3s) exhibited anticandidal activity in different ratios varying between the range of MIC: 50 and 200?µg/mL. |
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Keywords: | 2-Mercaptobenzothiazole anticandidal antifungal hydrazone |
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