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| 仿刺参多糖抗肿瘤及对荷瘤小鼠免疫调节作用 | |
| 引用本文： | 郭莲英,王璐,邹向阳,刘志远,刘宪丽,杨晓丹,侯林. 仿刺参多糖抗肿瘤及对荷瘤小鼠免疫调节作用[J]. 中国微生态学杂志, 2009, 21(9) |
| 作者姓名： | 郭莲英 王璐 邹向阳 刘志远 刘宪丽 杨晓丹 侯林 |
| 作者单位： | 1. 大连医科大学,生物技术专业,辽宁大连116044 2. 辽宁师范大学生命科学学院,辽宁大连,116027;大连工业大学生物与食品工程学院,辽宁大连116034 3. 辽宁师范大学生命科学学院,辽宁大连,116027 |
| 基金项目： | 辽宁省教育厅创新团队项目，大连市科技计划项目 |
| 摘 要： | 目的 观察仿刺参多糖(AJPS)抗肿瘤及免疫调节作用.方法 采用MTT法检测AJPS对人肝癌HepG-2细胞抑制率;以Hca-F肝癌小鼠为模型,采用MTT法、放免法测定荷瘤小鼠细胞免疫指标.结果 AJPS抑制HepG-2细胞生长,抑制小鼠移植瘤生长;增强脾淋巴细胞和巨噬细胞活性,促进TNF-α和IL-2的产生.结论 AJPS具有对HepG-2细胞的直接杀伤作用;AJPS对荷瘤小鼠有免疫调节活性,在肿瘤的免疫治疗中发挥作用. |
| 关 键 词： | 仿刺参多糖 Hep-G细胞 抗肿瘤 免疫调节 |
Antitumor and immunomodulating effects of Apostichopus japonicus polysaccharides (AJPS) in tumor-bearing mice |
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| GUO Lian-ying,WANG Lu,ZOU Xiang-yang,LIU Zhi-yuan,LIU Xian-li,YANG Xiao-dan,HOU Lin. Antitumor and immunomodulating effects of Apostichopus japonicus polysaccharides (AJPS) in tumor-bearing mice[J]. Chinese Journal of Microecology, 2009, 21(9) | |
| Authors: | GUO Lian-ying WANG Lu ZOU Xiang-yang LIU Zhi-yuan LIU Xian-li YANG Xiao-dan HOU Lin |
| Abstract: | Objective To investigate the antitumor and immunomodulating effects of Apostichopus japonicus polysaccharides( AJPS)in human tumor cell HepG-2 and tumor-bearing mice. Method Inhibition rate of AJPS on the HepG-2 cells was determined by MTT colormetry. The immunomological indexes of Hca-F hepatoma-bearing mice were detected by the method of MTT and radioimmunological analysis. Result AJPS could inhibit the growth of Hep-G cells and transplant tumor, enhance the activity of lymphocytes and Mψ,as well as promote the production of TNF-α and IL-2 induced from spleenocytes. Conclusion A JPS may have great effects on human Hep-G cells and hepatoma-besring mice and act as a biological modulator. |
| Keywords: | Apostichopus japonicus polysaccharides HepG-2 cell Antitumor Immunomodulation |
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