Body mass index and mortality in chronic obstructive pulmonary disease: a meta-analysis |
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Authors: | Chao Cao Ran Wang Jianmiao Wang Hansvin Bunjhoo Yongjian Xu Weining Xiong |
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Institution: | Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. |
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Abstract: | BackgroundThe association between body mass index (BMI) and mortality in patients suffering from chronic obstructive pulmonary disease (COPD) has been a subject of interest for decades. However, the evidence is inadequate to draw robust conclusions because some studies were generally small or with a short follow-up.MethodsWe carried out a search in MEDLINE, Cochrane Central Register of Controlled Trials, and EMBASE database for relevant studies. Relative risks (RRs) with 95% confidence interval (CI) were calculated to assess the association between BMI and mortality in patients with COPD. In addition, a baseline risk-adjusted analysis was performed to investigate the strength of this association.Results22 studies comprising 21,150 participants were included in this analysis. Compared with patients having a normal BMI, underweight individuals were associated with higher mortality (RR ?=?1.34, 95% CI ?=?1.01–1.78), whereas overweight (RR ?=?0.47, 95% CI ?=?0.33–0.68) and obese (RR ?=?0.59, 95% CI ?=?0.38–0.91) patients were associated with lower mortality. We further performed a baseline risk-adjusted analysis and obtained statistically similar results.ConclusionOur study showed that for patients with COPD being overweight or obese had a protective effect against mortality. However, the relationship between BMI and mortality in different classes of obesity needed further clarification in well-designed clinical studies. |
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