Protein kinase activity in mouse mammary carcinoma. |
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Authors: | G C Majumder |
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Institution: | St. Luke''s Hospital Research Foundation, Milwaukee, Wisconsin 53215 USA |
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Abstract: | C3H mouse mammary carcinoma contains cyclic AMP-independent (C) and dependent (RC) protein kinases and a specific cyclic AMP-binding protein (R). The specific activities of C, RC and R are markedly lower in carcinoma than the normal mammary cells. Protein kinase preparation from neoplastic cells showed markedly higher ration of and lower responsiveness to cyclic AMP for the activation of the enzyme than the normal cells. |
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