Possible Protective Effect of Kolaviron on CCl4-Induced Erythrocyte Damage in Rats |
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| Authors: | Oluwatosin A. Adaramoye Oluyemi Akinloye |
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| Affiliation: | (1) Laboratory for Biochemical/Molecular Toxicology, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria;(2) Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria |
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| Abstract: | The possible protective effect of kolaviron on rat erythrocytes followingsimultaneous administration of kolaviron (100 mg/kg of body weight/day) withcarbon tetrachloride CCl4 (1.195 g/kg of body weight/day) by separateintraperitoneal injections was investigated.Kolaviron, a biflavonoid fraction of the defatted alcoholic extract ofGarcinia kola seed, inhibits the accumulation of lipid peroxidationproducts in erythrocytes. A significant reduction (p>0.05) by about34% of lipid peroxidation products was observed in erythrocytes of ratstreated simultaneously with CCl4 and kolaviron when compared to CCl4-treatedrats. Similarly, the significant increase (p>0.05) in membranecholesterol observed in CCl4-treated rats was significantly decreased(p>0.05) in rats treated simultaneously with CCl4 andkolaviron. Therefore, there was no significant difference (p>0.05) incholesterol–phospholipid ratio (C/P) of rats treated simultaneouslywith CCl4 and kolaviron, and the controls. Thus, kolaviron normalizes theCCl4-induced change in erythrocyte membrane composition.In addition, kolaviron antagonizes the effect of CCl4 on the activity ofthe membrane bound enzyme, Ca2+-ATPase. These results suggest thatkolaviron protects erythrocyte membranes from free radical attack, on bothlipids and proteins. |
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| Keywords: | erythrocyte kolaviron CCl4 Ca2+-ATPase lipid peroxidation |
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