Synthesis of a trisulfated heparan sulfate disaccharide analog and its use as a template for preliminary molecular imprinting studies |
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Authors: | Ikeda Yasunori Siñeriz Fernando Bultel Laurent Grand Eric Kovensky José Papy-Garcia Dulce |
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Affiliation: | Laboratoire CRRET-UMR CNRS 7149, Faculté des Sciences et Technologie, Université Paris 12 Val de Marne, 61, Av. du Général de Gaulle, 94010 Créteil Cedex, France. |
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Abstract: | A heparan sulfate disaccharide analog was synthesized by a multistep route. This synthesis was designed in such a way that one intermediate could be selectively deprotected to provide versatility during both synthesis and homologation of heparan sulfate related polysaccharides. Non-covalent imprinted polymers were prepared by using the synthesized disaccharide as a template and a primary amine functionalized acrylate as the key functional monomer suitable for specific sulfated sugar recognition. The binding of related sugars to the imprinted and non-imprinted polymers and the binding of template to the chemically modified polymers have been also investigated. |
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Keywords: | Heparan sulfate Disaccharide Imprinting Molecular recognition |
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