CP-61,405, a novel polycyclic pyrrolether antibiotic produced byStreptomyces routienii Huang sp. nov.期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

CP-61,405, a novel polycyclic pyrrolether antibiotic produced byStreptomyces routienii Huang sp. nov.

Authors:	Walter P. Cullen Walter D. Celmer Larry R. Chappel Liang H. Huang Mark T. Jefferson Masaru Ishiguro Hiroshi Maeda Satoshi Nishiyama John R. Oscarson Riichiro Shibakawa Junsuke Tone

Affiliation:	(1) Central Research, Pfizer Inc., 06340 Nagoya, Japan;(2) Central Research, Pfizer Inc., 06340 Groton, CT, U.S.A.

Abstract:	Summary CP-61,405 (C₂₆H₂₉N₂O₇Na) is a novel polycyclic pyrrolether antibiotic produced by a new species,Streptomyces routienii Huang sp. nov. (ATCC 39446). Recovery, fractionation and purification were achieved using standard procedures. The crystalline form includes the CP-61,405 sodium salt, m.p. 334–335°C, []_D^25°C+315°C (c=1, chloroform). The structure is shown below. CP-61,405 was co-produced with the polycyclic ether antibiotics salinomycin and epi-17-deoxy-(0–8)-salinomycin. It exhibited activity in vitro against gram-positive and anaerobic bacteria, efficacy against poultry coccidia and stimulation in vitro of propionic acid production.

Keywords:	CP-61,405 Pyrrolether Streptomyces routienii Huang sp. nov. Anticoccidial agent
本文献已被 SpringerLink 等数据库收录！