Genes for the protein antigens of the tuberculosis and leprosy bacilli |
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| Authors: | Barry R Bloom Vijay Mehra Richard A Young |
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| Institution: | 1. Albert Einstein College of Medicine, 10461, New York, N.Y., USA
2. Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA
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| Abstract: | The lambda gt 11 expression vector permitted us to survey protein antigens of Mycobacterium leprae and Mycobacterium tuberculosis expressed in Escherichia coli. Using monoclonal antibodies, recombinant clones were detected producing three major antigens of M. tuberculosis and five major protein antigens of M. leprae. These recombinant antigens produced in E. coli should prove useful for diagnosis, epidemiology and possibly the development of recombinant mycobacterial vaccines. |
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