The Effects of Caffeine on <Emphasis Type="SmallCaps">l</Emphasis>-Arginine Metabolism in the Brain of Rats |
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Authors: | Ebru Ofluoglu Hatice Pasaoglu Aydın Pasaoglu |
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Institution: | (1) Faculty of Medicine, Department of Medical Biochemistry, Gazi University, Beşevler, Ankara, 06510, Turkey;(2) Faculty of Medicine, Department of Neurosurgery, Gazi University, Ankara, Turkey |
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Abstract: | In our study, the short-term effects of caffeine on L- arginine metabolism in the brains of rats were investigated. Caffeine
was given orally at two different doses: 30 mg/kg and 100 mg/kg (a high non-toxic dose). Brain tissue arginase activity in
rats from the caffeine-treated groups decreased significantly compared with the control group. Malondialdehyde (MDA) levels
in the brain tissue and serum of animals in the caffeine groups also decreased significantly. Brain tissue and serum nitric
oxide (NO) levels increased significantly after caffeine administration. Tumor necrosis factor-α (TNF-α) levels were also
investigated in rat serum, but there was no statistically significant difference between the TNF-α levels of the caffeine-treated
rats groups and the control rats. Our study indicates that brain arginase activity decreases after caffeine administration
at doses of 30 mg/kg and 100 mg/kg. As a result, we can say that arginine induces production of NO in the organism. |
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Keywords: | Caffeine Arginase Malondialdehyde Nitric oxide |
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