ERYTHROPOIETIN SENSITIVITY OF RAT BONE MARROW CELLS SEPARATED BY VELOCITY SEDIMENTATION |
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| Authors: | Dorothy McCool R J Miller R H Painter W R Bruce |
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| Institution: | Departments of Biochemistry and Medical Biophysics, University of Toronto |
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| Abstract: | Rat bone marrow cells have been separated on the basis of their sedimentation at unit gravity. The cell population most responsive to erythropoietin in vitro was found to have a sedimentation velocity of about 6.6 mm/hr. In the process of becoming hemoglobin-synthesizing cells, it undergoes cell division and its sedimentation velocity decreases to 3.9 mm/hr and then to 2.1 mm/hr, the sedimentation velocity of mature red blood cells. |
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