Background neuronal activity in thenucleus supraopticus and its modifications under the influence of parathyroid hormone |
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Authors: | A A Asratyan D N Khudaverdyan K G Bagdasaryan P Sh Sarkisyan |
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Institution: | (1) Geratsi State Medical University, Yerevan, Republic of Armenia;(2) Orbeli Institute of Physiology, National Academy of Sciences of Armenia, Yerevan, Republic of Armenia |
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Abstract: | In experiments on anesthetized cats, we found that i. v. injection of 5.0 U/kg of parathyroid hormone (PTH) results in modifications
of the statistical parameters of the neuronal impulse activity in thenucleus supraopticus (SO) of the hypothalamus. Sliding frequency graphs, histograms of interspike intervals, autocorrelograms, and serial correlation
coefficients were plotted and calculated before and after PTH injections; their comparison demonstrates that the hormone significantly
modulates the temporal organization of spike trains generated by the neurons of this nucleus. We observed that PTH mostly
activated SO neurons and diminished the level of spike grouping in their activity. The effect of PTH to a certain level depended
on the initial frequency of background activity: an increase in the spiking frequency was typical of primarily dominating
“low-frequency” neurons, while “high-frequency” units were mostly inhibited. The possible mechanisms of the observed modifications
are discussed. |
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Keywords: | |
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