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Animal models reveal role for tau phosphorylation in human disease |
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| Authors: | Jürgen Götz Amadeus Gladbach Luis Pennanen Janet van Eersel Andreas Schild Della David Lars M Ittner |
| Institution: | 1. Alzheimer''s and Parkinson''s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, New South Wales 2050, Australia;2. University of California, San Francisco, Department of Psychiatry, Rock Hall, 1550 4th Street, San Francisco, CA 94158-2822, USA;3. Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;4. University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94158-2517, USA |
| Abstract: | Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention. |
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