Cadmium and mitochondria |
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| Authors: | Giuseppe Cannino Elisa Ferruggia Claudio Luparello Anna Maria Rinaldi |
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| Affiliation: | 1. Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Jiangsu Key Laboratory for Microbes and Functional Genomics, College of Life Sciences, Nanjing Normal University, Nanjing 210023, PR China;2. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA;3. Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA;1. College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an City, Shandong Province 271018, China;2. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai’an City, Shandong Province 271018, China;3. Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai’an City, Shandong Province 271018, China;4. Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;5. Shandong Provincial Center for Animal Disease Control and Prevention, Ji’nan City, Shandong Province 250022, China;1. Department of Biological Sciences, School of Life Science, Liaoning University, Chongshan Road 66, Shenyang, 110036, PR China;2. The Ninth People’s Hospital of Shenyang, South Eleven West Road 18, Shenyang, 110036, PR China;3. School of Environment, Liaoning University, Chongshan Road 66, Shenyang, 110036, PR China;1. Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, No. 1101 Zhimin Avenue, Economic and Technological Development District, Nanchang 330045, Jiangxi, PR China;2. School of Information Technology, Jiangxi University of Finance and Economics, No. 665 Yuping West street, Economic and Technological Development District, Nanchang 330032, Jiangxi, PR China;1. College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, China;2. Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University, Yangling 712100, Shaanxi, China |
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| Abstract: | The heavy metal cadmium (Cd) a pollutant associated with several modern industrial processes, is absorbed in significant quantities from cigarette smoke, water, food and air contaminations.It is known to have numerous undesirable effects on health in both experimental animals and humans, targeting kidney, liver and vascular system.The molecular mechanism accounting for most of the biological effects of Cd are not well-understood and the toxicity targets are largely unidentified.The present review focuses on important recent advances about the effects of cadmium on mitochondria of mammalian cells.Mitochondria are the proverbial powerhouses of the cell, running the fundamental biochemical processes that produce energy from nutrients using oxygen. They are among the key intracellular targets for different stressors including Cd.This review provides new additional informations on the cellular and molecular aspects of the interaction between Cd and cells, emphasizing alterations of mitochondria as important events in Cd cytotoxicity, thus representing an important basis for understanding the mechanisms of cadmium effect on the cells. |
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