Mitochondrial function and energy metabolism in cancer cells: Past overview and future perspectives |
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| Authors: | Avraham Mayevsky |
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| Institution: | 1. Department of Chemistry, ICET, Federal University of Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, CEP 78060-900 Cuiabá, MT, Brazil;2. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;3. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy;5. Department of Dermatology, Boo Ali Sina (Avicenna) Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;1. Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China;2. Anesthesiology Research Institute, Central South University, Changsha 410011, Hunan, China;3. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA;4. Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China;1. Department of Neurology, Westfälische Wilhelms University, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany;2. WIAS Berlin, Mohrenstraße 39, 10117 Berlin, Germany |
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| Abstract: | The involvements of energy metabolism aspects of mitochondrial dysfunction in cancer development, proliferation and possible therapy, have been investigated since Otto Warburg published his hypothesis. The main published material on cancer cell energy metabolism is overviewed and a new unique in vivo experimental approach that may have significant impact in this important field is suggested. The monitoring system provides real time data, reflecting mitochondrial NADH redox state and microcirculation function. This approach of in vivo monitoring of tissue viability could be used to test the efficacy and side effects of new anticancer drugs in animal models. Also, the same technology may enable differentiation between normal and tumor tissues in experimental animals and maybe also in patients. |
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