Preparative HPLC resolution of the CIS cyclohexane analogs of phenylalanine |
| |
Authors: | Alías M Cativiela C Jiménez A I López P Oliveros L Marraud M |
| |
Institution: | Departamento de Química Orgánica, ICMA, Universidad de Zaragoza-CSIC, Zaragoza, Spain. |
| |
Abstract: | The analytical resolution of different derivatives of cis c(6)Phe (cyclohexane analogs of phenylalanine) was tested by HPLC using the mixed 10-undecenoate/3,5-dimethylphenylcarbamate of amylose bonded on allylsilica gel as the chiral stationary phase. The same chiral support has allowed the enantioseparation of racemate cis-4 on a semipreparative column (150 x 20 mm ID) with a mixture of n-hexane/2-propanol/chloroform as the mobile phase. Some 200-300 mg of the optically pure enantiomers were isolated and transformed into the N-benzyloxycarbonyl amino acids. The X-ray diffraction structure of (1R;2R)-4 is reported. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|