On the probability of interaction between elementary radiation-induced chromosomal injuries |
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Authors: | D J Brenner |
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Institution: | (1) Radiological Research Laboratory, Department of Radiation Oncology, College of Physicians & Surgeons of Columbia University, 630 W. 168 Street, 10032 New York, NY, USA |
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Abstract: | Summary Within the Theory of Dual Radiation Action, the heuristically useful function, ( ), that two energy depositions, a distance apart, will result in observable damage can be written in terms of two more fundamental quantities: One,s( ), describes the structure of the sensitive matrix of the cell. The other,g( ), describes the probability that two elementary injuries, a distance apart, will combine to produce observable damage. A priori, the known enhancement exhibited byy( ) at nanometer separations could be due to an enhancement ofs( ),g( ) or both. For the endpoint of chromatid exchanges in Chinese hamster cells, ( ) has been evaluated from experimental data ands( ) from a model system. From theseg( ) has been estimated and is roughly constant below 1 µm, decreasing rapidly at larger separations. Thus the enhanced short-range effect appears to be a function more of the spatial characteristics of the target rather than the probability of damage interaction. |
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