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Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats |
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| Authors: | Alexander S Finch Maria Moldovan Jonathan Frank Robert Bagnell Laurence M Katz Robert D Pearlstein |
| Institution: | 1. Medical Free Electron Laser Laboratory and Multidisciplinary Neuroptrotection Laboratories, Department of Surgery/Neurosurgery, Box 3388 DUMC, Duke University Durham, NC 27710, USA;2. Department of Emergency Medicine, University of North Carolina Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27599, USA;3. Proton Neuroscience Research Laboratory, Department of Radiation Medicine, Loma Linda University, 11175 Campus St, A1010 CSP, Loma Linda, CA 92350, USA;4. Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA |
| Abstract: | The purpose of this study was to determine if mild hypothermia alters mitotic activity in normal and post-ischemic hippocampal slices. (1) Normothermic oxygen–glucose deprivation (OGD 60 min) increased mitotic activity in the hippocampus up to 4d post-OGD. (2) Mild hypothermia (33 °C for 24 h) initiated after OGD stress reduced mitotic activity compared to normothermic controls up to 8 d post-OGD. (3) Mild hypothermia stimulated mitotic activity in normal (no OGD stress) hippocampus up to 24 h post-hypothermia. In conclusion, mild transient hypothermia can increase or decrease mitotic activity depending upon the experimental condition of the hippocampal slices when hypothermia is induced. |
| Keywords: | Neuroprotection Astrocytosis Reactive gliosis Cell proliferation Hypothermia Thermobiology Brain ischemia |
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