Dose-dependent effects of chronic iron burden on heart aldehyde and acyloin production in mice |
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Authors: | Matthew T Davis Wally J Bartfay |
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Institution: | (1) School of Nursing, Queen’s University, Kingston, Ontario, Canada;(2) Faculty of Nursing, University of Windsor, Windsor, Ontario, Canada |
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Abstract: | Iron’s chemical structure and its ability to initiate one-electron reactions are properties that cause it to play a major
role in the production and metabolism of oxygen free radicals in biological systems. Oxygen free radicals are conjectured
to cause cardiac failure in individuals afflicted with disorders of iron overload. We report on the use of both acyloins and
aldehydes as markers of oxidative stress in a murine model of chronic iron-overload cardiomyopathy. Twenty mice were randomized
to four treatment groups: (1) control (0.2 mL normal saline ip/mouse/d); (2) 100 mg iron (0.05 mL iron dextran/mouse/d); (3)
200 mg iron (0.1 mL iron dexxtran/mouse/d); (4) 400 mg iron (0.2 mL iron dextran/mouse/d). Significant dose-dependent increases
in both total heart aldehyde and total heart acyloin concentrations were found. Furthermore, a significant positive correlation
existed between the dose of iron administered and each quantified aldehyde and acyloin found in the heart. |
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Keywords: | Iron acyloin aldehyde oxygen free radical heart cardiomyopathy |
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