Genetic control of B- and T-Lymphocyte abnormalities of NZB mice in crosses with B10.D2 mice |
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Authors: | Dr Wendy F Davidson LMI NIAID Thomas M Chused Herbert C Morse III |
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Institution: | (1) Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20205 Bethesda, Maryland;(2) National Institutes of Health, Building 5 Room 218, 20205 Bethesda, Maryland |
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Abstract: | Parental NZB and B10.D2, F1 and F1 × B10.D2 mice were studied to determine the genetic control of (1) altered B-cell IgD expression, (2) plasma cell frequency, (3) IgM secretion per plasma cell, (4) primary in vitro cytotoxic T-cell responses to H-2-compatible cells, (5) production of thymocyte-binding antibodies, and (6) production of red-cell-specific antibodies. The results demonstrate that, in this cross, IgD abnormalities and production of red-cell-specific antibodies were recessive traits. There was a common genetic influence on plasma cell frequency, IgM secretion per plasma cell and production of thymocyte-binding antibodies which was distinct from the genes governing the ability to generate a cytotoxic T lymphocyte response to H-2-compatible cells.Abbreviations used in this paper CTL
cytotoxic T lymphocyte
- F1 anti-Fab
fluorescein-labeled antimouse Fab
- FMF
flow microfluorometry
- Ig
immunoglobulin
- IgM/PC
IgM secretion per PC
- PC
plasma cell
- sIg
surface immunoglobulin
- TBA
thymocyte-binding antibody |
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