| 从microarray时序表达数据识别周期表达基因 |
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| 引用本文： | 周到,何东,周艳红. 从microarray时序表达数据识别周期表达基因[J]. 生物信息学, 2008, 6(2): 68-70 |
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| 作者姓名： | 周到 何东 周艳红 |
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| 作者单位： | 华中科技大学生物信息与分子成像湖北省重点实验室,湖北,武汉,430074 |
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| 基金项目： | 国家自然科学基金 , 科技部科技基础条件平台建设计划 |
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| 摘 要： | 根据周期表达基因的周期性和峰值特点，提出了一种将microarray时序表达数据划分为若干个基因表达周期，并对周期内的峰值特点进行评估以识别周期表达基因的方法，能有效减小microarray实验时的噪声干扰。选取了三组广泛使用的时序表达数据和一组可靠的周期表达基因集合对该方法的效果进行了测试，并与三种典型的周期表达基因识别方法的效果进行了比较。该方法能有效地从各种microarray时序表达数据中识别周期表达基因。
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| 关 键 词： | 周期表达基因 表达周期 micmarmy 时序表达 峰值特性 |
| 文章编号： | 1672-5565(2008)-02-68-03 |
| 修稿时间： | 2006-11-23 |
Identifying periodically expressed genes from microarray data |
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| ZHOU Dao,HE Dong,ZHOU Yan-hong. Identifying periodically expressed genes from microarray data[J]. Chinese Journal of Bioinformatics, 2008, 6(2): 68-70 |
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| Authors: | ZHOU Dao HE Dong ZHOU Yan-hong |
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| Affiliation: | ZHOU Dao, HE Dong, ZHOU Yah- hong ( Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong Uni. of Sci. ＆ Tech., Wuhan 430074, China ) |
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| Abstract: | According to the periodic peak trait of periodically expressed genes, we have developed a novel method which can deal with the disturbance in microarray time series data, and obtain more accurate identification of periodically expressed genes. A comparison between our method and other three methods was made by applying three different cell cycle expression data using one benchmark. The results demonstrate that our method is effective in the analysis of expression data with disturbances. |
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| Keywords: | periodically expressed genes cell cycle gene expression data peak trait |
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