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Expression of GLP-1R protein and its clinical role in intrahepatic cholangiocarcinoma tissues |
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| Authors: | Ben-Dong Chen Wen-Chao Zhao Jian-Da Dong Hui Sima |
| Institution: | 1. Department of Hepatobiliary Surgery, General Hospital of NingXia Medical University, Yinchuan, 750004, Ningxia, People’s Republic of China 2. Department of Hepatobiliary Surgery, Navy Hospital, Beijing, 100086, People’s Republic of China 3. Pathology Department of Basic Medical Sciences School, NingXia Medical University, Yinchuan, 750004, Ningxia, People’s Republic of China 4. Department of Fifth Hepatic Surgery, Eastern hepatobiliary surgery hospital of Secong Militery Medical University, Shanghai, 200438, People’s Republic of China |
| Abstract: | The study investigates the expression and clinical role of GLP-1R in intrahepatic cholangiocarcinoma (ICC) tissues. ICC tissue, tissue around tumour and normal liver tissue samples from 176 ICC patients were investigated for GLP-1R expression by immunohistochemistry and western blots. Expression levels were correlated to clinical variables and to the postoperative outcome. High GLP-1R expression levels were detected in tumor tissue samples. Kaplan–Meier method was used for survival analysis of patients follow-up data. Results showed that median survival time of patients with high GLP-1R positive expression in ICC tissue were 22 months. Median survival time of patients with low GLP-1R positive expression in ICC tissue were 19.8 months. There wasn’t statistical difference (p = 0.332) between two groups. Immunohistochemistry semi-quantitative analysis showed that tissue differentiation is not prognostic risk factors. In patients with GLP-1R positive expression in ICC tissue, lymph node metastasis was important prognostic factors (p = 0.001). Although statistical analysis showed that GLP-1R can not be judged as a risk prognostic factors, GLP-1 might become a new target for therapy of ICC. |
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