Polycomb-group proteins in the initiation and progression of cancer |
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| Affiliation: | 1. State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Cancer Institute and Hospital, Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China;2. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China;1. Department of Biochemistry, University of Oxford, South Parks Rd., Oxford OX1 3QU, UK;1. Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy;2. École Polytechnique Fédérale de Lausanne (EPFL), ISREC, Lausanne CH-1015, Switzerland;3. Developmental Genetics Group, RIKEN Research Centre for Allergy & Immunology (RCAI), 1-7-22 Suehiuro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan;1. Department of Genetics, Yale University, New Haven, CT 06520, USA;2. Department of Cell Biology, Yale University, New Haven, CT 06520, USA;3. Department of Pathology, Yale University, New Haven, CT 06520, USA;4. Yale Stem Cell Center, Yale University, New Haven, CT 06520, USA;5. Department of Genetics, Cell Biology and Development, University of Minnesota, and the Masonic Cancer Center, Minneapolis, MN 55455, USA;6. Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Cell Biology, New York University School of Medicine, New York, NY10016, USA |
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| Abstract: | The Polycomb group(PcG) proteins are a family of chromatin regulators and critical for the maintenance of cellular identity. The PcG machinery can be categorized into at least three multi-protein complexes, namely Polycomb Repressive Complex 1(PRC1), PRC2, and Polycomb Repressive De UBiquitinase(PR-DUB).Their deregulation has been associated with human cancer initiation and progression. Here we review the updated understanding for Pc G proteins in transcription regulation and DNA damage repair and highlight increasing links to the hallmarks in cancer. Accordingly, we discuss some of the recent advances in drug development or strategies against cancers caused by the gain or loss of PcG functions. |
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| Keywords: | Polycomb group Polycomb repressive complex Cancer Epigenetic Transcription regulation |
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