Application of conductance measurements to drug mode of action studies |
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| Authors: | L.D. Dale D.I. Edwards |
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| Affiliation: | Chemotherapy Research Unit, Polytechnic of East London, Romford Road, London E15 4LZ, UK |
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| Abstract: | The cytotoxic properties of 1-(2-nitro-1-imidazolyl)-3-(1-aziridinyl)-2-propanol (RSU-1069) on wild-type Escherichia coli and mutants defective in specific DNA repair have been studied. Comparison of the conductance curves obtained for each mutant strain with various drug concentrations allows determination of the processes involved in the repair of drug-induced damage and from this the type of damage induced may be determined. Automated conductance measurements can be used as a model system for studying modes of drug action. |
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