Glutathione mixed disulfide inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase |
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| Authors: | Hyangsook Chung Josef Fried Elisabeth Williams-Ashman Joseph Jarabak |
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| Affiliation: | 1. Privolzhsky Research Medical University, Nizhny Novgorod, Russia;2. V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg, Russia;3. Nizhny Novgorod Clinical Psychiatric, Hospital No. 1, Nizhny Novgorod, Russia;4. Nizhny Novgorod Research Institute for Hygiene and Occupational Pathology, Nizhny Novgorod, Russia;5. Pushchino State Institute of Natural Science, Pushchino, Russia |
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| Abstract: | Six glutathione-containing inhibitors of the human NADP-linked 15-hydroxyprostaglandin dehydrogenase have been isolated from placental homogenates. Glutathione disulfide is one of these inhibitors. Although the structures of the other five have not been fully elucidated, all are disulfides. Studies with these compounds and with other mixed disulfides have shown that the glutathione mixed disulfides of β-mercaptopyruvate, mercaptoacetate, and β-mercaptolactate are more effective inhibitors of the enzyme than are the glutathione-containing mixed disulfides isolated from placental homogenates. β-Mercaptolactate is particularly noteworthy because of its low Kj (0.13 μM). The results reported here suggest that the activity of the prostaglandin dehydrogenase may be influenced by various glutathione mixed disulfides. |
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