A lipid dependence in the formation of twin ion channels |
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| Authors: | Al-Momani Lo'ay Reiss Philipp Koert Ulrich |
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| Affiliation: | Fachbereich Chemie, Philipps-Universit?t Marburg, Hans-Meerwein Strasse, D-35032 Marburg, Germany. |
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| Abstract: | A gramicidin A derivative with a polyether linkage between both ethanolamine termini was synthesized and its ion channel properties were studied. The compound showed a duplication in the state of conductance for alkali cations in thick DOPC bilayer membranes, which is interpreted as the occurrence of twin-channels. In thinner DMPC membranes mono-channels were dominant. The influence of hydrophobic coupling on the mono channel/twin channel equilibrium is discussed. |
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| Keywords: | Gramicidin A Ion channel Bilayer membrane Twin-channel Hydrophobic coupling |
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