The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein |
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Authors: | Wiedemann M Trueb B |
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Affiliation: | M.E. Müller-Institute, University of Bern, P.O. Box 30, CH-3010, Bern, Switzerland. |
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Abstract: | The mouse Fgfrl1 gene codes for a novel cell surface protein that is closely related to the family of the FGF receptors. It contains three extracellular Ig C2 loops and an acidic box, which share 29-33% sequence identity (48-50% similarity) with FGF receptors 1-4. The intracellular portion of the novel protein, however, lacks a tyrosine kinase domain required for signal transduction by transphosphorylation. The gene for Fgfrl1 comprises six exons and is located on mouse chromosome 5 in close proximity to the Idua gene for L-iduronidase. |
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