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A novel family of single VWC-domain proteins in invertebrates
Authors:Sheldon T J  Miguel-Aliaga I  Gould A P  Taylor W R  Conklin D
Institution:Division of Mathematical Biology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. tsheldon@nimr.mrc.ac.uk
Abstract:Using a combination of sequence analysis tools, a novel family of 13 short Drosophila melanogaster proteins with similarity to a single von Willebrand factor C-domain (SVC proteins) has been identified. SVCs are predicted to be secreted and a structural model for the family is proposed, using a known von Willebrand factor C-domain (VWC) structure as template. All SVCs possess eight cysteines, consistent with the loss of one bonded pair from the 10-cysteine canonical pattern of most VWC domains. Unlike most Drosophila genes, many SVCs are not expressed during development, and misexpression has no apparent effect on development or viability. SVCs appear to be restricted to arthropods. A role for SVCs in response to environmental challenges is proposed.
Keywords:von Willebrand factor  VWC  Vago  Drosophila
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