| 青叶胆中齐墩果酸的制备工艺及其纯度测定 |
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| 引用本文： | 李开泉,曾晓敏.青叶胆中齐墩果酸的制备工艺及其纯度测定[J].生物加工过程,2012,10(4):38-41. |
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| 作者姓名： | 李开泉 曾晓敏 |
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| 作者单位： | 1. 江西省天然药物活性成分研究重点实验室,宜春336000;宜春学院化学与生物工程学院,宜春336000
2. 宜春学院教育科技园,宜春,336000 |
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| 基金项目： | 国家高技术研究发展计划(863计划)资助项目 |
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| 摘 要： | 研究青叶胆中齐墩果酸的提取工艺及其结构鉴定。用体积分数95%乙醇回流提取2次,每次1.5 h,减压回收乙醇后用水洗涤得沉降物。用YCXY-2号除杂剂处理后,加活性炭脱色30 min 2次,经凝析分离、纯化精制得齐墩果酸产品。采用理化常数测定和薄层色谱、红外光谱、质谱及核磁共振光谱鉴定试样的化学结构,确定实验所得产品为齐墩果酸,而齐墩果酸为青叶胆的主要化学成分。
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| 关 键 词： | 提取分离 齐墩果酸 青叶胆 |
Preparation of oleanolic acid from Swertia mileensis and its purity determination |
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| LI Kaiquan
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ZENG Xiaomin.Preparation of oleanolic acid from Swertia mileensis and its purity determination[J].Chinese Journal of Bioprocess Engineering,2012,10(4):38-41. |
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| Authors: | LI Kaiquan ZENG Xiaomin |
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| Institution: | 1.Key Laboratory of Province for Research on Active Ingredients in Natural Medicines,Yichun 336000,China; 2.Chemical and Biological Engineering Department,Yichun University,Yichun 336000,China; 3.Education Science and Technology Park,Yichun University,Yichun 336000,China) |
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| Abstract: | The extraction process of oleanolic acid from Swertia mileensis was investigated and its structure was identified.Samples of Swertiae mileensis Herba were refluxed with 95% ethanol for 2 times,each time for 1.5 h.After treated with YCXY-2 and activated carbon for 30 min 2 times,the condensate was separated and the refined oleanolic acid was obtained.The oleanolic acid was confirmed by physicochemical constant determination,infrared spectrum analysis,mass spectrometric analysis,and NMR spectrum analysis. |
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| Keywords: | extraction oleanolic acid Swertia mileensis |
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