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The coupling of the relative movement of thea andc subunits of the F0 to the conformational changes in the F1-ATPase |
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| Authors: | Susan M Howitt Andrew J W Rodgers Lyndall P Hatch Frank Gibson Graeme B Cox |
| Institution: | (1) Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National Unversity, GPO Box 334, 2601 Canberra, ACT, Australia;(2) Present address: Institute of Molecular Biology, University of Oregon, 97403 Eugene, Oregon |
| Abstract: | F0F1-ATPase structural information gained from X-ray crystallography and electron microscopy has activated interest in a rotational mechanism for the F0F1-ATPase. Because of the subunit stoichiometry and the involvement of both thea- andc-subunits in the mechanism of proton movement, it is argued that relative movement must occur between the subunits. Various options for the arrangement and structure of the subunits involved are discussed and a mechanism proposed. |
| Keywords: | F0F1-ATPase rotation a- b- and c-subunits |
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