The effect of water on protein dynamics |
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Authors: | Zaccai G |
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Institution: | Institut de Biologie Structurale, 41 rue Jules Horowitz, Grenoble Cedex 1, France. zaccai@ibs.fr |
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Abstract: | Neutron diffraction and spectroscopy were applied to describe the hydration and dynamics of a soluble protein and a natural membrane from extreme halophilic Archaea. The quantitative dependence of protein motions on water activity was clearly illustrated, and it was established that a minimum hydration shell is required for the systems to access their functional resilience, i.e. a dynamics state that allows biological activity. |
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