Potential role of CagA in the inhibition of T cell reactivity in Helicobacter pylori infections |
| |
Authors: | Paziak-Domańska B Chmiela M Jarosińska A Rudnicka W |
| |
Affiliation: | Department of Infectious Biology, University of Lodz, Lodz, 90-237, Poland. |
| |
Abstract: | The pathogenicity of chronic gastroduodenal diseases is very often related to Helicobacter pylori infections. Most H. pylori strains carry the cagA gene encoding an immunodominant 120- to 128-kDa protein which is considered a virulence marker. The majority of CagA-positive H. pylori isolates also produce a 95-kDa protein cytotoxin (VacA) causing vacuolation and degradation of mammalian cells. In our previous study we have shown that live H. pylori bacteria and their sonicates inhibit PHA-driven proliferation of human T lymphocytes. The H. pylori CagA and VacA proteins were suspected of a paralyzing effect of H. pylori on T cell proliferation. In this report, by using isogenic H. pylori mutant strains defective in CagA and VacA proteins, we determined that CagA is responsible for the inhibition of PHA-induced proliferation of T cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|