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Finding of carotenoids in the vitreous body of human eye during prenatal development |
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| Authors: | M. A. Yakovleva I. G. Panova T. B. Fel’dman P. P. Zak A. S. Tatikolov G. T. Sukhikh M. A. Ostrovsky |
| Affiliation: | (1) Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia;(2) Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991, Russia;(3) Research Center of Obstetrics, Gynaecology, and Perinatology, Russian Academy of Medical Sciences, ul. Akademika Oparina 4, Moscow, 117997, Russia |
| Abstract: | Carotenoids were found for the first time in the vitreous body of human eye during the fetal period from week 15 until week 28. Their maximum content was timed to week 16–22. No carotenoids were found the vitreous body of 31-week fetuses, as well as adult humans, which corresponds to the published data. It was shown using HPLC that chromatographic characteristics of these carotenoids correspond to those of lutein and zeaxanthin, characteristic pigments of the retinal yellow macula. |
| Keywords: | carotenoids macular pigment albumin vitreous body retina lens development spectrophometry HPLC |
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