|
|||||
|
|
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs) |
|
| Authors: | Mulvihill Mark J Kan Julie L C Beck Patricia Bittner Mark Cesario Cara Cooke Andrew Keane David M Nigro Anthony I Nillson Christy Smith Vanessa Srebernak Mary Sun Feng-Lei Vrkljan Michael Winski Shannon L Castelhano Arlindo L Emerson David Gibson Neil |
| Institution: | OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. mark.mulvihill@osip.com |
| Abstract: | A series of 2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's). |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |