New type of polyubiquitin-like genes with intein-like autoprocessing domains |
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Authors: | Dassa Bareket Yanai Itai Pietrokovski Shmuel |
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Affiliation: | Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel 76100. |
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Abstract: | Genome analysis of ciliates identified a new type of polyubiquitin-like genes. These contain tandem repeats of ubiquitin-like domains interspersed with autocatalytic intein-like domains. Inteins and related protein domains post-translationally process their own precursor proteins by protein-splicing, cleavage and ligation reactions. The structure of these polyubiquitin-like genes suggests their precursor products undergo maturation and conjugation in cis. This novel gene structure also illustrates the genetic modularity of ubiquitin-like and intein-like domains. Our suggested autoprocessing of ubiquitin-like polyproteins is a new potential general way for controlling protein functions. |
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