Inhibition of species of the Aspergillus section Nigri and ochratoxin a production in grapes by fusapyrone |
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Authors: | Favilla Mara Pascale Michelangelo Ricelli Alessandra Evidente Antonio Amalfitano Carmine Altomare Claudio |
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Institution: | Istituto di Scienze delle Produzioni Alimentari, CNR, Via Giovanni Amendola 122/O, 70125 Bari, Italy. |
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Abstract: | Fusapyrone (FP), an antifungal natural compound, was tested against the three main ochratoxigenic species of the Aspergillus section Nigri. The MICs at 24 h were 6.0, 11.6, and 9.9 mug/ml for Aspergillus carbonarius, Aspergillus tubingensis, and Aspergillus niger, respectively. Strong inhibition of growth and morphological changes were still observed at half the MIC after 7 days. The application of a 100 mug/ml FP solution in a laboratory assay on artificially inoculated grapes resulted in a significant reduction (up to 6 orders of magnitude) of A. carbonarius CFU counts. Dramatic reductions of the ochratoxin A (OTA) content, compared to the content of the positive control (average amount of OTA, 112.5 ng/g of grape; three experiments), were obtained with the application of either 100 or 50 mug/ml of FP (0.6 or 5.1 ng/g of grape, respectively). |
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