MycoProtease-DB: Useful resource for Mycobacterium tuberculosis complex and nontuberculous mycobacterial proteases |
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| Authors: | Lingaraja Jena Satish Kumar Bhaskar Chinnaiah Harinath |
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| Institution: | Bioinformatics Centre, JB Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram (Wardha) 442102, Maharashtra, India |
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| Abstract: | MycoProtease-DB is an online MS SQL and CGI-PERL driven relational database that domiciles protease information of
Mycobacterium tuberculosis (MTB) complex and Nontuberculous Mycobacteria (NTM), whose complete genome sequence is
available. Our effort is to provide comprehensive information on proteases of 5 strains of Mycobacterium tuberculosis (H37Rv, H37Ra,
CDC1551, F11 and KZN 1435), 3 strains of Mycobacterium bovis (AF2122/97, BCG Pasteur 1173P2 and BCG Tokyo 172) and 4 strains
of NTM (Mycobacterium avium 104, Mycobacterium smegmatis MC2 155, Mycobacterium avium paratuberculosis K-10 and Nocardia
farcinica IFM 10152) at gene, protein and structural level. MycoProtease-DB currently hosts 1324 proteases, which include 906
proteases from MTB complex with 237distinct proteases & 418 from NTM with 404 distinct proteases. Flexible database design and
easy expandability & retrieval of information are the main features of MycoProtease-DB. All the data were validated with various
online resources and published literatures for reliable serving as comprehensive resources of various Mycobacterial proteases.AvailabilityThe Database is publicly available at http://www.bicjbtdrc-mgims.in/MycoProtease-DB/ |
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| Keywords: | Mycobacterium tuberculosis complex Database Protease NTM |
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