Sister chromatid exchanges and chromosome aberrations in fibroblasts from patients with retinoblastoma |
| |
| Authors: | T Takabayashi M S Lin Miriam G Wilson |
| |
| Institution: | (1) Genetics Division, Department of Pediatrics, Los Angeles County-University of Southern California Medical Center, 90033 Los Angeles, CA, USA;(2) University of Southern California School of Medicine, 90033 Los Angles, CA, USA;(3) Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Seiryo-machi 1-1, Seudai, Japan |
| |
| Abstract: | Summary The frequencies of sister chromatid exchanges (SCEs) and chromosome breaks were investigated in five diploid fibroblast strains derived from three patients with deletion 13del(13)] retinoblastoma, one patient with a hereditary form of retinoblastoma, and one trisomy 13. The fibroblasts with del(13)(q14q22) showed slightly increased SCEs (at a P level of 5–10%), but the others, including del(13)(q12q14), the hereditary form of retinoblastoma, and trisomy 13, did not have increased SCEs as compared to normal controls. No increase in chromosome breaks was found in these fibroblasts. The results suggest that retinoblastoma is not associated with spontaneous increased chromosomal instability. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
