Effect of Different Iodine Nutrition on Cerebellum Pcp-2 in Rat Offspring During Lactation |
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Authors: | Lu Zhang Yi Na Sun Yong Mei Li Lai Xiang Lin Yan Ye Yu Qin Yan Zu Pei Chen |
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Institution: | (1) Institute of Endocrinology, Tianjin Medical University, Key Lab of Hormones and Development, Ministry of Health, 22, Qi-Xiang-Tai Road, 300070 Tianjin, China;(2) Present address: Medical College of Chinese People’s Armed Police Forces, Tianjin, China; |
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Abstract: | The thyroid functions of breastfed infants, as well as (indirectly) the development of their central nervous system, are dependent
on the iodine status of the lactating mother. Purkinje cell protein-2 is a cell-specific marker of the cerebellum Purkinje
cell and is a suitable indicator for observing the postnatal development of the cerebellum after birth. We measured the Purkinje
cell protein-2 mRNA and protein levels in the rat cerebellum in the critical postnatal (14 days after birth) and maturation
periods (28 days after birth) to determine the effect of different nutritional iodine levels on cerebellum growth in the offspring
during lactation. We found that severe iodine deficiency resulted in thyroid dysfunction in lactating rats and their offspring
on both 14 and 28 days, showing maternal total T4 16.7 ± 12.0 vs 36.4 ± 15.0, P < 0.05 (14 days) and 22.6 ± 18.7 vs 53.4 ± 9.4, P < 0.01 (28 days), and neonatal total T4 10.6 ± 2.3 vs 16.4 ± 4.7, P < 0.01(14 days) and 12.8 ± 2.9 vs 16.7 ± 3.4, P < 0.05 (28 days), respectively. The Purkinje cell protein-2 mRNA and its protein levels in offspring rats were significantly
reduced that showed Purkinje cell protein-2 mRNA 1.12 ± 0.04 vs 2.25 ± 0.53, P < 0.05 (14 days) and 1.74 ± 0.94 vs 8.69 ± 2.71, P < 0.01 (28 days). However, mild iodine deficiency and excessive iodine maintained almost normal thyroid function in maternal
and neonatal rats and normal Purkinje cell protein-2 mRNA and protein levels in offspring’s cerebellum. We conclude that severe
iodine deficiency could significantly reduce Purkinje cell protein-2 mRNA and its protein levels, indicating that the cerebellum
development was retarded, but mild iodine deficiency and excessive iodine could maintain them at an approximately normal level
by the mother’s and offspring’s compensations, especially by the mother’s mammary glands. |
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