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Lipid Peroxidation Induced by NAD(P)H and NAD+-Dependent Substrates in Soybean Mitochondria
Authors:Vianello  Angelo; Macri  Francesco; Bindoli  Alberto
Institution:1Section of Plant Physiology and Biochemistry, Institute of Plant Protection, University of Udine 1-33100 Udine, Italy
2Centre for the Study of Mitochondrial Physiology, C.N.R., 1-35100 Padooa and Institute of Biological Chemistry, University of Padova 1-35100 Padova, Italy
Abstract:Lipid peroxidation induced by Fe2+{oslash}ADP in soybean mitochondriais stimulated by pyruvate, malate (in the presence of NAD2+)and by NAD(P)H. This lipid peroxidation is almost completelyinhibited by EDTA indicating that iron is essential. Also salicylhydroxamicacid, a specific inhibitor of the alternate oxidase, is a stronginhibitor of lipid peroxidation but its effect should be relatedto chelation or to a general antioxidant action. Rotenone doesnot show any effect on the malate{oslash}NAD2+{oslash}Fe2+{oslash}ADP-induced lipidperoxidation. From the reported data, it is possible to concludethat, in soybean mitochondria, the peroxidation of unsaturatedlipids can be modulated through a balance between the systemssparking lipid peroxidation, like NAD(P)H{oslash} Fe2+{oslash}ADP, and the systemswhich protect against it, i.e. quinones, maintained at the reducedstate by the substrates. (Received April 20, 1987; Accepted July 21, 1987)
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